Cued fear extinction is controlled by stathmin and GRPR in opposite directions.

<p>(<b>A</b>) Protocol used for acquisition (left) and extinction (right) of cued fear conditioning. (<b>B</b>) Acquisition (left) and extinction (right) performances of GRPR WT and KO mice (11 WT and 12 KO). (<b>C</b>) Acquisition (left) and extinction (right) performances of stathmin WT and KO mice (16 WT and 11 KO). Acquisition performance is expressed as percentage of freezing during tone-shock pairings and extinction performance is expressed as percentage of freezing during 5 blocks (4 tones) for 4 days of extinction. Results are presented as mean ± SEM. R, renewal. *represents significant difference between groups during one block of a daily session; # represents significant difference between groups during the whole extinction phase.