Thrombin generation phenotypes in an hypothetical population defined by normal range variation in factor levels.

<p>Each individual in the population (6,561) is defined by 4 thrombin parameters and their phenotype represented graphically by a positioned colored circle: y axis—time to 2 nM thrombin, range (2.3→15 min); x axis—maximum rate of thrombin generation, range (0.1→12.4 nM/s); color—maximum thrombin level, range (23 (dark blue)→792 nM(brown)); and size—total thrombin, range (8,179•→134,340 sec•nM ○). Inset: An individual with all factors at their mean physiologic value is depicted, the arrow indicating that individual's position in the population. Similarly, representative individuals from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030385#pone-0030385-g002" target="_blank">Figure 2</a> panels B and C are included.