<p>Plasma factor composition for 32 individuals was used to generate time courses of thrombin generation, thrombin parameters were extracted and each individual represented as described in the legend to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030385#pone-0030385-g003" target="_blank">Figure 3</a>. The boundaries (magenta) of the theoretical population are outlined and an individual with all factors at their mean physiologic values is also presented. Arroe indicates an individual with all factors at mean physiological.</p
<p>A computationally-simulated time course of thrombin generation with all factors at their mean phy...
Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system th...
<p>Thrombin generation was started with 0.5 pM TF and 16.7 mM CaCl<sub>2</sub>. The parameters depic...
<p>Each individual in the population (6,561) is defined by 4 thrombin parameters and their phenotype...
<p>Plasma factor composition was used to generate time courses of thrombin generation, thrombin para...
<p>Individuals were selected with disparate factor composition, but similar thrombin generation prof...
<div><p>In terms of its soluble precursors, the coagulation proteome varies quantitatively among app...
In terms of its soluble precursors, the coagulation proteome varies quantitatively among apparently ...
<p>Thrombin generation profiles were generated from each individual’s plasma composition (n = 364), ...
In vitro thrombin generation, which reflects an individual's plasma coagulation potential and has be...
<p>FVIII concentration for each variant was adjusted to 5 ng/ml in complete medium. Subsequently eac...
The tendency of a plasma sample to generate thrombin, a central enzyme in blood coagulation, might b...
<p>Individuals within the family were segregated by gender for <b>A)</b> Protein C mutation, <b>B)</...
Thrombin generation may be a potential tool to improve risk stratification for cardiovascular diseas...
<p>Thrombin generation was started with 0.5 pM TF and 16.7 mM CaCl<sub>2</sub>. The parameters depic...
<p>A computationally-simulated time course of thrombin generation with all factors at their mean phy...
Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system th...
<p>Thrombin generation was started with 0.5 pM TF and 16.7 mM CaCl<sub>2</sub>. The parameters depic...
<p>Each individual in the population (6,561) is defined by 4 thrombin parameters and their phenotype...
<p>Plasma factor composition was used to generate time courses of thrombin generation, thrombin para...
<p>Individuals were selected with disparate factor composition, but similar thrombin generation prof...
<div><p>In terms of its soluble precursors, the coagulation proteome varies quantitatively among app...
In terms of its soluble precursors, the coagulation proteome varies quantitatively among apparently ...
<p>Thrombin generation profiles were generated from each individual’s plasma composition (n = 364), ...
In vitro thrombin generation, which reflects an individual's plasma coagulation potential and has be...
<p>FVIII concentration for each variant was adjusted to 5 ng/ml in complete medium. Subsequently eac...
The tendency of a plasma sample to generate thrombin, a central enzyme in blood coagulation, might b...
<p>Individuals within the family were segregated by gender for <b>A)</b> Protein C mutation, <b>B)</...
Thrombin generation may be a potential tool to improve risk stratification for cardiovascular diseas...
<p>Thrombin generation was started with 0.5 pM TF and 16.7 mM CaCl<sub>2</sub>. The parameters depic...
<p>A computationally-simulated time course of thrombin generation with all factors at their mean phy...
Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system th...
<p>Thrombin generation was started with 0.5 pM TF and 16.7 mM CaCl<sub>2</sub>. The parameters depic...