Neutrophil depletion partly inhibits skin blistering induced by BP180/CXVII-specific IgG in mice.

<p>Mice pre-immunized with rabbit IgG and injected i.p. with BP180/CXVII-specific rabbit IgG were treated with (<b>A</b>) a Ly-6G-specific monoclonal or (<b>B</b>) a mock antibody as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031066#s4" target="_blank">Materials and Methods</a> (arrows). (<b>C</b>) Disease activity during the depletion of Ly-6G-positive cells is significantly reduced in the group of mice treated with Ly-6G-specific antibody (n = 5) compared with the group treated with mock antibody (n = 5; p<0.05). Data are shown as mean ± SD.