Toll-like receptors (TLRs) are pattern recognition receptors that recognize specific molecular patterns present in molecules that are broadly shared by pathogens but are structurally distinct from host molecules. The TLR7-agonistic imidazoquinolines are of interest as vaccine adjuvants given their ability to induce pronounced Th1-skewed humoral responses. Minor modifications on the imidazoquinoline scaffold result in TLR7-antagonistic compounds which may be of value in addressing innate immune activation-driven immune exhaustion observed in HIV. We describe the syntheses and evaluation of TLR7 and TLR8 modulatory activities of dimeric constructs of imidazoquinoline linked at the C2, C4, C8, and <i>N</i><sup>1</sup>-aryl positions. Dimers li...
Toll-like receptor 7 (TLR7) is a class of pattern recognition receptors (PRRs) recognizing the patho...
Human Toll-like receptor 8 (hTLR8) is expressed in myeloid dendritic cells, monocytes, and monocyte-...
Toll-Like Receptors (TLR) are a large family of proteins involved in the immune system response. Bot...
Toll-like receptors (TLRs) are pattern recognition receptors that recognize specific molecular patte...
Engagement of toll-like receptors serve to link innate immune responses with adaptive immunity and c...
Engagement of toll-like receptors (TLRs) serve to link innate immune responses with adaptive immunit...
Engagement of toll-like receptors (TLRs) serve to link innate immune responses with adaptive immunit...
Engagement of toll-like receptors (TLRs) serve to link innate immune responses with adaptive immunit...
Toll-like receptors (TLRs)-7/-8 are among pathogen recognition receptors (PRRs) present in the endos...
Toll-like receptors (TLR) -7 and -8 are thought to play an important role in immune activation proce...
Engagement of toll-like receptors (TLRs) serve to link innate immune responses with adaptive immunit...
Imidazoquinoline derivatives (IMDs) and related compounds function as synthetic agonists of Toll-lik...
Toll-like receptor (TLR)-8 agonists strongly induce the production of T helper 1-polarizing cytokine...
Toll-like receptor (TLR)-8 agonists typified by the 2-alkylthiazolo[4,5-c]quinolin-4-amine (CL075) c...
We present the synthesis of novel adjuvants for vaccine development using multivalent scaffolds and ...
Toll-like receptor 7 (TLR7) is a class of pattern recognition receptors (PRRs) recognizing the patho...
Human Toll-like receptor 8 (hTLR8) is expressed in myeloid dendritic cells, monocytes, and monocyte-...
Toll-Like Receptors (TLR) are a large family of proteins involved in the immune system response. Bot...
Toll-like receptors (TLRs) are pattern recognition receptors that recognize specific molecular patte...
Engagement of toll-like receptors serve to link innate immune responses with adaptive immunity and c...
Engagement of toll-like receptors (TLRs) serve to link innate immune responses with adaptive immunit...
Engagement of toll-like receptors (TLRs) serve to link innate immune responses with adaptive immunit...
Engagement of toll-like receptors (TLRs) serve to link innate immune responses with adaptive immunit...
Toll-like receptors (TLRs)-7/-8 are among pathogen recognition receptors (PRRs) present in the endos...
Toll-like receptors (TLR) -7 and -8 are thought to play an important role in immune activation proce...
Engagement of toll-like receptors (TLRs) serve to link innate immune responses with adaptive immunit...
Imidazoquinoline derivatives (IMDs) and related compounds function as synthetic agonists of Toll-lik...
Toll-like receptor (TLR)-8 agonists strongly induce the production of T helper 1-polarizing cytokine...
Toll-like receptor (TLR)-8 agonists typified by the 2-alkylthiazolo[4,5-c]quinolin-4-amine (CL075) c...
We present the synthesis of novel adjuvants for vaccine development using multivalent scaffolds and ...
Toll-like receptor 7 (TLR7) is a class of pattern recognition receptors (PRRs) recognizing the patho...
Human Toll-like receptor 8 (hTLR8) is expressed in myeloid dendritic cells, monocytes, and monocyte-...
Toll-Like Receptors (TLR) are a large family of proteins involved in the immune system response. Bot...