A schematic diagram of cell states and a snapshot of the multicellular model.

<p>(A) each cell lives in the “Normal” state until a HIV virus infects it. An “Infected” cell doesn't release new virions until a certain time point post infection, denoted <i>t</i>_prod. At this time point, the cell becomes “Productive” and begins releasing viruses into the extracellular environment until it dies at <i>t</i>_dead, when it is marked as “Dead”. The “Infected(+)” and “Infected(−)” states correspond to cells that have been infected by A3G(+) and A3G(−) viruses, respectively. The same concept applies to “Productive(+)” and “Productive(−)” cells. (B) The time of infection is known for each cell in our multicellular model. A snapshot of the multicellular model shows cells with different post-infection ages in the sets of infected and productive cells. Normal cells become infected and enter the set of infected cells as early-infected cells. The late-infected cells become productive and leave the set of infected cells to join the set of productive cells where they are shown as early-productive cells. Finally, late-productive cells die, exit the set of productive cells, and get marked as dead.