Validation of the model via simulation of agonist bath application.

<p>(A) Change in phosphoThr34 DARPP-32 is similar to that observed experimentally in response to 10 µM dopamine alone, 600 nM calcium alone (inset), and the combination of dopamine with calcium. (B) Decrease in phosphoThr75 DARPP-32 for same three conditions as (A). (C) Change in phosphoSer845 GluA1 for same three conditions as (A). All responses are similar to experimental measurements.