AT location affects the remodeling phenotype of human AT macrophages in obese individuals.

<p>A, Transcript levels of angiogenic and matrix remodeling/fibrotic factors were determined by real-time PCR analyses of ATM immunoselected from paired biopsies of subcutaneous (Sc) and omental AT (Om). Results are expressed as fold differences between Om and Sc and are means ± SEM (n = 22 subjects, mean BMI 43.9±1.4 kg/m²). Open bars: genes up-regulated, and solid bars: genes down-regulated, in OmATM <i>vs</i> ScATM. B, Transcript levels of <i>HIF-1α</i> and <i>-2α</i> determined by real-time PCR analyses of ScATM and OmATM. Values are means ± SEM (AU, arbitrary unit) of the 22 paired biopsies. * P<0.05 and *** P<0.001 <i>vs</i> Om.