Impaired vascular remodeling in congenic eNOS knockout mice.

<p>(A) Morphometric analysis showing reductions in lumen diameter of LC in C57BL/6J mice with no change in wall thickness in response to a remodeling stimulus, yet no change in lumen diameter but an increase in wall thickness in LC of eNOS (−/−) mice. (B) Hematoxylin and eosin staining showing RC and remodeled LC from a C57BL/6J mouse (upper panel) and RC and remodeled LC from an eNOS (−/−) mouse (lower panel). Scale bar represents 25 µm. Values are mean ± SEM; * P<0.05, ** P<0.01 with one way ANOVA with Bonferroni posttest; n = 5 for each group of mice.