Group mean waveforms of wheel running activity in rats from Cohort A (panels A–C) and Cohort B (panels D–F).

<p>Panels A,D: ad-lib food access (grey shading) and 37-h food deprivation prior to restricted feeding (red curve). Panels B,E: Restricted feeding (RF) days (black line) prior to 2 days food deprivation (FD, red line) in constant dark (DD). Panels C,F: RF days (black line) prior to omission of both meals for one day (red line) in LD. Other plotting conventions as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031772#pone-0031772-g001" target="_blank">Figure 1</a>.