<p>Methylation in genomic features along with Intron retention class of alternative splicing events was calculated. Genomic features include RefSeq exons, introns, identified liver expressed gene exons and introns. Three bins were created: 1) 200 bp upstream from start site of the event, 2) from start site to end of the event, 3) 200 bp downstream from the end. Peak summit count obtained in all bins was normalized by dividing the count with the area of that bin. Distribution of peak summit count in 10 bp sliding window, 200 bp upstream and downstream from the start site of all RefSeq exons and cassette exons.</p
To determine the impact of the intron-exon architecture and splice site strength on splice site sele...
Integration of transcriptome data is a crucial step for the identification of rare protein variants ...
Ensus value (CV) method. Donor and acceptor sites are considered separately. The vertical dashed lin...
<p>(A) Counts of alternatively spliced and non-alternatively spliced genes with different methylatio...
Abstract DNA methylation is presently accepted as a tentative regulatory parameter in splicing. Rece...
<p>Distribution of peak summit count in 10 bp sliding window, 200 bp upstream and downstream from th...
<p>A) Feature annotation of all cytosines and methylated cytosines. Annotations are shown for all th...
<p>(A) Number of splicing events and genes detected for 5 classes of alternative splicing events: ca...
<p>Exons involved in alternative splicing exhibit little difference in DNA methylation between contr...
<p>The red curve depicts the difference in the fractional methylation levels of skipped exons (in ex...
BACKGROUND: Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases the...
rMATS (https://rnaseq-mats.sourceforge.io/) was used to identify differential alternative splicing e...
BACKGROUND: Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases the...
SummaryThe global impact of DNA methylation on alternative splicing is largely unknown. Using a geno...
Thousands of alternative exons are spliced out of messenger RNA to increase protein diversity. High-...
To determine the impact of the intron-exon architecture and splice site strength on splice site sele...
Integration of transcriptome data is a crucial step for the identification of rare protein variants ...
Ensus value (CV) method. Donor and acceptor sites are considered separately. The vertical dashed lin...
<p>(A) Counts of alternatively spliced and non-alternatively spliced genes with different methylatio...
Abstract DNA methylation is presently accepted as a tentative regulatory parameter in splicing. Rece...
<p>Distribution of peak summit count in 10 bp sliding window, 200 bp upstream and downstream from th...
<p>A) Feature annotation of all cytosines and methylated cytosines. Annotations are shown for all th...
<p>(A) Number of splicing events and genes detected for 5 classes of alternative splicing events: ca...
<p>Exons involved in alternative splicing exhibit little difference in DNA methylation between contr...
<p>The red curve depicts the difference in the fractional methylation levels of skipped exons (in ex...
BACKGROUND: Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases the...
rMATS (https://rnaseq-mats.sourceforge.io/) was used to identify differential alternative splicing e...
BACKGROUND: Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases the...
SummaryThe global impact of DNA methylation on alternative splicing is largely unknown. Using a geno...
Thousands of alternative exons are spliced out of messenger RNA to increase protein diversity. High-...
To determine the impact of the intron-exon architecture and splice site strength on splice site sele...
Integration of transcriptome data is a crucial step for the identification of rare protein variants ...
Ensus value (CV) method. Donor and acceptor sites are considered separately. The vertical dashed lin...