Restored XBP-1 expression reduced miR-214 overexpression induced HCC tumor suppression in vitro and in vivo.

<p>(<b>A</b>) XBP-1 reintroduced reversed the suppression of colony formation induced by agomir-214 treatment in SMCC-7721 cells. (<b>B</b>) XBP-1 reintroduced reversed the suppression of tumor formation induced by agomir-214 treatment in nude mouse SMCC-7721 cells xenograft model. Tumor weight 4 weeks after inoculation was measured. (<b>C</b>) XBP-1 reintroduced reversed the suppression of cells proliferation induced by agomir-214 treatment in SMCC-7721 cells. The results were reproducible in three independent experiments. *P<0.05 vs agomir-NC-treated; #P<0.05 vs agomir-214 or agomir-214+vector-treated.