<p>Summary of time constants of activation for all mutants at A, <i>V</i> = <i>V</i><sub>0.5</sub>+40 mV and B, <i>V</i> = <i>V</i><sub>0.5</sub>+180 mV. Filled bars indicate values that are statistically significantly different to WT (* p<0.05, *** p<0.001).</p
<p>We defined WT as 1. Except for R22Q, all other mutations resulted in significant downregulation i...
<p>A. Representative currents of WT, E446A, D452A, E464A, E470A, and E475A Ano1, activated by 180<su...
<p>(A) Family of current traces recorded during a 3 s isochronal activation protocol for (i) WT and ...
<p>Summary of time constants of deactivation for all mutants at <i>V</i> = <i>V</i><sub>0.5</sub>−40...
<p>The energy perturbation caused by mutations for steady-state activation, rates of activation and ...
<p>A. Three state transition model, which includes a low voltage sensitivity step (C1 – C2) and a hi...
<p>The <i>G<sub>max</sub></i> and <i>V<sub>0.5</sub></i> of activation were determined from the <i>I...
<p>A. Examples of tail currents recorded at −70 mV from (i) WT and (ii) A548V channels after varying...
<p>The average RMSF of the mutated residues for 10 ns are plotted in 2D bar graph. The bars in gray ...
<p><b>A.</b> Mean values of the variables of availability (I/I<sub>max</sub>) of WT and mutant hKv4....
<p>A. Typical examples of families of current traces recorded from (i) WT and (ii) Y542A channels du...
<p>(A) Current traces correspond to dotted box in the voltage protocol used to measure the recovery ...
<p>Rate constants (k) of heteroaggregates of αB-wt and αA-wt and its mutants at the acceptor, 515 nm...
<p><i>Km</i> (µM) and <i>Vmax</i> values were calculated for CL-EAAT1 and single cysteine mutants wi...
<p>(<b>A</b>) C root mean square fluctuations of mutants compared to the wild-type. The values repor...
<p>We defined WT as 1. Except for R22Q, all other mutations resulted in significant downregulation i...
<p>A. Representative currents of WT, E446A, D452A, E464A, E470A, and E475A Ano1, activated by 180<su...
<p>(A) Family of current traces recorded during a 3 s isochronal activation protocol for (i) WT and ...
<p>Summary of time constants of deactivation for all mutants at <i>V</i> = <i>V</i><sub>0.5</sub>−40...
<p>The energy perturbation caused by mutations for steady-state activation, rates of activation and ...
<p>A. Three state transition model, which includes a low voltage sensitivity step (C1 – C2) and a hi...
<p>The <i>G<sub>max</sub></i> and <i>V<sub>0.5</sub></i> of activation were determined from the <i>I...
<p>A. Examples of tail currents recorded at −70 mV from (i) WT and (ii) A548V channels after varying...
<p>The average RMSF of the mutated residues for 10 ns are plotted in 2D bar graph. The bars in gray ...
<p><b>A.</b> Mean values of the variables of availability (I/I<sub>max</sub>) of WT and mutant hKv4....
<p>A. Typical examples of families of current traces recorded from (i) WT and (ii) Y542A channels du...
<p>(A) Current traces correspond to dotted box in the voltage protocol used to measure the recovery ...
<p>Rate constants (k) of heteroaggregates of αB-wt and αA-wt and its mutants at the acceptor, 515 nm...
<p><i>Km</i> (µM) and <i>Vmax</i> values were calculated for CL-EAAT1 and single cysteine mutants wi...
<p>(<b>A</b>) C root mean square fluctuations of mutants compared to the wild-type. The values repor...
<p>We defined WT as 1. Except for R22Q, all other mutations resulted in significant downregulation i...
<p>A. Representative currents of WT, E446A, D452A, E464A, E470A, and E475A Ano1, activated by 180<su...
<p>(A) Family of current traces recorded during a 3 s isochronal activation protocol for (i) WT and ...
DOI
Add to ORKG