Onset of striatal neuropathology in YAC128 mice.

<p><b>A</b>) Total dendritic length of WT mice (Veh + Mn) increased from week 13 to week 16, but was unchanged in YAC128 mice (Veh + Mn). <b>B</b>) Total dendritic length increased in WT-Veh mice from week 13 to week 16, but was unchanged in YAC128-Veh mice. <b>C</b>) Total spine density decreased from 13 to 16 weeks in both WT mice (Veh + Mn) and YAC128 mice (Veh + Mn). YAC128 mice had significantly higher total spine density than WT mice at 16 weeks. <b>D</b>) Total spine density decreased in WT-Veh mice from 13 to 16 weeks, but there was no significant change in total spine density of YAC128-Veh mice. Week 13: n = 4–5 mice per group, 4–6 neurons/animal. Week 16: n = 5 mice/group, 4–6 neurons/animal. Average values +/− SEM; p-values from <i>post-hoc</i> t-tests are on each graph, significant differences within each genotype between weeks 13 and 16 are indicated in bold, significant differences within a given time point between genotypes are indicated by (**).