Functional miRNA groups and their representation in genomic clusters.

<p>The figure displays, to which extend the similarities in miRNA responses are reflected by their genomic origin. First, 133 miRNAs were selected based on their presence in all samples. Then, these 133 miRNAs were ordered according to their similarities in their responses to pro-inflammatory stimuli (lower half of the cluster; similarity measure: Spearman-rank correlation). Finally, the 133 miRNAs were ordered according to their similarity of their genomic origin (upper half of the cluster; similarity measure: absolute distance in kilobases). When similarities on the response level are mirrored on the genomic level, a group of miRNAs with similar response patterns have a shared genomic origin.