<p>Panels a–f show the percentages of cells expressing the markers indicated on the vertical axis by time interval since onset. Each line represents an individual patient. Panel g shows the relationship between the percentages of CD8 T cells that are CD38+HLADR+ and CD27+CD28− and includes results for all time points. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031535#s2" target="_blank">Results</a> are shown for 10 patients with severe influenza (red tones symbols and lines) and 39 patients with mild influenza (blue tone symbols and lines).</p
<p>Box-plot graph showing the level of exhaustion (PD1 and Tim3 markers) on different subsets of CD8...
<p>Representative flow cytometry plots of subjects without (top) or with (bottom) significant day 0 ...
<p>Dot plots represent (A), absolute numbers of NK cells (B), percentages of total NK cells and (C),...
<p>The percentages (a) and absolute count (b) of CD8 T cells with the phenotypes CXCR3<sup>high</sup...
<p><b>A.</b> The panel illustrates the positive correlation between early change in TERT expression ...
<p>Shown is the percentage of CD4 T-cells (left graphs) and CD8 T-cells (right graphs) expressing CD...
<p>(A) CD38 and Ki67 co-expressing cells in the total CD8 T cell population over time in one represe...
<p>Box plots show the 10<sup>th</sup>, 25<sup>th</sup>, 50<sup>th</sup> (median), 75<sup>th</sup> an...
Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we show circul...
<p>A) Cells were labeled for flow cytometry and percentage positive calculated using FlowJo. All don...
<p>Flow cytometric profiles of Flu, EBV and CMV-specific CD8 T cells expressing PD-1, CD160 and 2B4 ...
Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we show circul...
<p>A) Representative FACS plots and bar graphs of percent of total CD8 T cells specific for NP<sub>3...
<p>(<b>A</b>) Comparison of PD-1 expression on influenza RA9 tetramer-positive CD8 T-cells (top) and...
<p>(A) Representative IFN-γ expression frequency in human CD8<sup>+</sup> and CD4<sup>+</sup> cells ...
<p>Box-plot graph showing the level of exhaustion (PD1 and Tim3 markers) on different subsets of CD8...
<p>Representative flow cytometry plots of subjects without (top) or with (bottom) significant day 0 ...
<p>Dot plots represent (A), absolute numbers of NK cells (B), percentages of total NK cells and (C),...
<p>The percentages (a) and absolute count (b) of CD8 T cells with the phenotypes CXCR3<sup>high</sup...
<p><b>A.</b> The panel illustrates the positive correlation between early change in TERT expression ...
<p>Shown is the percentage of CD4 T-cells (left graphs) and CD8 T-cells (right graphs) expressing CD...
<p>(A) CD38 and Ki67 co-expressing cells in the total CD8 T cell population over time in one represe...
<p>Box plots show the 10<sup>th</sup>, 25<sup>th</sup>, 50<sup>th</sup> (median), 75<sup>th</sup> an...
Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we show circul...
<p>A) Cells were labeled for flow cytometry and percentage positive calculated using FlowJo. All don...
<p>Flow cytometric profiles of Flu, EBV and CMV-specific CD8 T cells expressing PD-1, CD160 and 2B4 ...
Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we show circul...
<p>A) Representative FACS plots and bar graphs of percent of total CD8 T cells specific for NP<sub>3...
<p>(<b>A</b>) Comparison of PD-1 expression on influenza RA9 tetramer-positive CD8 T-cells (top) and...
<p>(A) Representative IFN-γ expression frequency in human CD8<sup>+</sup> and CD4<sup>+</sup> cells ...
<p>Box-plot graph showing the level of exhaustion (PD1 and Tim3 markers) on different subsets of CD8...
<p>Representative flow cytometry plots of subjects without (top) or with (bottom) significant day 0 ...
<p>Dot plots represent (A), absolute numbers of NK cells (B), percentages of total NK cells and (C),...