Effects of Gis1 and Rph1 on glycerol, acetate and acetyl-CoA metabolism.

<p>(A) Effects of <i>gis1</i> and <i>rph1</i> mutations on gene expression after the diauxic shift. The columns show fold changes and p-values for different genetic contrasts in PDS cells and after 3 days of culture. Genes that are significantly (p<0.02) downregulated in a mutant are shown in green and those that are upregulated in red. Genes are shown in red/green are upregulated in the <i>gis1</i> mutant and downregulated in the <i>rph1</i> mutant. Also shown are the number of STRE and PDS motifs in each promoter. (B) Glycerol and acetate metabolic pathways in yeast. The effects of Gis1 and Rph1 on genes encoding some key enzymes are shown. It should be noted that regulation in several cases is likely to be indirect, being mediated by the repression or activation of some other transcription factor.