Mutant TDP-43 and FUS aggregate in vivo.

<p>(A) Representative image of a fixed <i>unc-47p::GFP;mTDP-43</i> worm stained with a human TDP-43 antibody. The green channel shows GFP labelled motor neurons. Antibody staining (red signal) revealed aggregation of TDP-43 signals in motor neurons. Staining of motor neuron nuclei with DAPI (blue signal) revealed that TDP-43 is both cytoplasmic (single arrowhead) and nuclear (double arrowhead). Scale bar represents 10 µm for all photos. (B) Staining of <i>unc-47p::GFP;mFUS</i> worms with a human FUS antibody (red signal) and DAPI (blue signal) revealed cytoplasmic (single arrowhead) and nuclear (double arrowhead) accumulations in motor neurons.