Cytotoxic effects induced by different tested drugs on SP and non-SP cell fractions isolated from highly tumorigenic and invasive WPE1-NB26 cells.

<p>The SP and non-SP WPE1-NB26 cell fractions were untreated or treated with the indicated concentrations of gefitinib, LY294002, pAkt inhibitor VIII, partenolide, anti-MIC-1 antibody or docetaxel for 72 hours and the cell viability was analyzed by MTT tests. The data are the means of at least three different experiments done in triplicate. *, <i>P</i><0.05, indicates a significant difference between the cytotoxic effects induced by individual drugs on the SP cells <i>versus</i> the non-SP WPE1-NB26 cell fraction.