Nearest centroid classification of MDD and healthy control subjects.

<p>Six edges (listed on the right) selected using nearest centroid analysis classified subjects into MDD and control groups, with classification indicated by the dendrogram at the top of the figure. Individual subjects are represented by the terminal branches of the dendrogram, with MDD subjects clustering toward the right (indicated by black bars in the top row) and control subjects clustering toward the left (indicated by red bars) in the supervised cluster analysis. Data values for each subject are indicated by a color column in the heatmap corresponding to a terminal branch. MDD subjects tended to have higher coherence values than controls on edges involving frontopolar electrodes, while controls tended to have higher coherence on the edge involving parietooccipital electrodes (indicated by green-to-yellow colors in the heatmap). As part of the clustering algorithm, the coherence values were scaled to have zero mean and unit variance across the subjects (as shown in colorbar).