cTOH3/aTOH1 and aTOH4 regions under-represented in lung cancer cases compared to controls.

<p>Single-SNP association analysis was performed independently of TOH analysis and compared. The significant associations of single SNPs, and each TOH with lung cancer cases versus controls, and their respective 95% CI (colored dashed lines), are shown. Below each of the lower panels are candidate gene names (multi-colored) which were prioritized after testing for association between lung cancers and differential expression of each of the genes within and +/− 250 kb of the TOH, stratified by smoking status (p<0.0001; see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031975#s2" target="_blank">Methods</a> section). <b>A.</b> cTOH3/aTOH1 region (2 p16.3–16.1; brown line) significantly under-represented in lung cancer cases and GWAS-identified SNPs (purple dots) in the same region (top panel) with their respective corresponding risks as odds ratios (lower panel). <b>B.</b> aTOH4 (7q21.11; brown line) significantly under-represented in lung cancer cases and GWAS-identified SNPs (purple dots) in the region (top panel) with their corresponding lung-cancer risks as odds ratios (OR; lower panel).