Clustering of gene expression profiles for genes residing within significant c/aTOH +/−250 kb regions.

<p>Bi-clustering of relative gene expression (horizontal) classified by “LC (tumor)+smoking status” and “normals+smoking status” (vertical). The acquisition, re-standardization and merging of expression array data with TOH regions are detailed in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031975#s2" target="_blank">Methods</a> section. Red coloration on the heat map is relative over-expression of the genes, blue denotes relative under-expression and white no distinct relative expressional difference observed. The heat map represents the differential expression profiles of 47 genes that were selected after univariate analysis (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031975#s2" target="_blank">Methods</a> section for details). The expression profiles of genes residing within and in proximity to the c/aTOH regions that are associated with tobacco use differentiate lung carcinomas from normal lung tissue.