Ancestral (F0 generation female) exposures to environmental compounds promote transgenerational diseases, altering onset of puberty, testicular spermatogenic function and ovarian follicular development in F3 generation rat progeny.

<p>(A) Onset of female puberty was advanced from exposures to plastics, dioxin and jet fuel. (B) Onset of male puberty was unaffected from these exposures. (C) Increased apoptotic spermatogenic cells per testis section were observed from jet fuel exposure. (D) Total numbers of ovarian follicles per section were reduced in individuals from all exposures, (E) Total numbers of primordial follicles per section declined. (F) Total numbers of large ovarian antral follicles were unaffected. The animal n value is presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031901#pone.0031901.s007" target="_blank">Table S1C</a> (*p<0.05; **p<0.01, ***p<0.001).