Model-based nucleosome occupancy profiles for sonicated H3K4me1 ChIP-Seq data.

<p>Panels show nucleosome positioning within bp from the top-ranked <i>in vivo</i> transcription factor binding sites that PICS detected for (A) SPI1 and (B) CEBPB from sonicated H3K4me1 ChIP-Seq data for 0 hour (blue) and 1 hour (red) after tamoxifen stimulation <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032095#pone.0032095-Heinz1" target="_blank">[20]</a>. The heatmaps show nucleosome prediction profiles for each region as pairs of blue/red horizontal lines, with darker colors indicating higher scoring, i.e. better positioned, nucleosomes. The lower part of each heatmap shows genomic regions that lack detectable nucleosome positioning. Curves below each heatmap show average occupancy profiles across all TF regions.