Transfer of naïve CD3+ T cells into RAG-1^−/− mice restores rapid protection by MVA vaccination.

<p>Vaccinated RAG-1^−/− mice (◊) or vaccinated RAG-1^−/− mice that received naïve CD3+ spleen cells two days before immunization with MVA (○) were challenged with 3×LD₅₀ ECTV two days after vaccination. Groups of RAG-1^−/− mice that received naïve CD3+ spleen cells served as mock-challenged (▪) or mock-vaccinated (▴) controls. In all experiments weight loss of individual mice was monitored daily (n = 3 to 6 per group). +indicate the individual time of death. Error bars indicate SEMs, and the numbers of surviving/total animals are given in parentheses. Data are representative of two similar experiments. Statistical significance of differences between groups is indicated by * for p-value<0.05, ** for p-value<0.01 and *** for p-value<0.001.