Simultaneous estimation of hidden model states (including intracellular calcium concentrations) and maximal conductances in a two-compartment model of a vertebrate motoneuron (II).

<p>Inference of maximal conductances and noise parameters during fixed-lag smoothing. (<b>A</b>) The standard deviations of the observation (Ai) and the intrinsic (Aii) noise at the soma and the dendrite. (<b>B</b>) Inferred maximal conductances of the sodium and potassium currents at the soma (Bi), of the N-type calcium current and the calcium-activated potassium current at the soma (Bii), of the calcium-activated potassium current at the dendrite (Biii) and of the N-type and L-type calcium currents at the dendrite (Biv). In all cases, parameter expectations gradually converged towards the true parameter values (dashed lines) after less than . The grey lines in Aii, Biii and Biv correspond to estimated parameters, when current was injected in the soma only. In these simulations, , , and the prior interval for was .