Enantioselective Gold-Catalyzed Synthesis of Polycyclic Indolines

The synthesis of architecturally complex polycyclic fused indolines is achieved in a chemo-, regio-, and stereodefined manner, via an enantioselective gold-catalyzed cascade hydroindolination/iminium trapping synthetic sequence. Highly functionalized tetracyclic fused furoindolines (<b>2</b>) and dihydropyranylindolines (<b>4</b>) are synthesized in moderate to good yields and enantiomeric excesses of up to 87%