New bone formation and mineralization determined histomorphometrically by TE, CA, and AL fluorescent quantification, which represent the mineralization level at 12 weeks after the operation (A).

<p>Parts a, b, c, d, and e are confocal laser scanning microscopy images for each group. Parts a4, b4, c4, d4, and e4 represent merged images of the three fluorochromes for the same group. Parts a5, b5, c5, d5, and e5 represent the merged images of the three fluorochromes together with the plain confocal laser microscopy image for the same group. (B) The graph shows the percentage of each fluorochrome area in each group. (** <i>P</i><0.01, target gene groups compared with the GFP group, Blank group or CMPC group; #, <i>P</i><0.05, the cHIF group compared to the HIF group).