Neogenin increases inflammatory cytokine release <i>in-vivo</i>.

<p><i>Neo1^−/−</i> and <i>WT</i> animals were injected i.p. with NaCl or 1 mg of zymosan A (ZyA) and peritoneal lavage obtained after 8 hours <b>A</b>) TNF-α concentration in peritoneal lavage of <i>Neo1^−/−</i> and WT animals <b>B</b>) IL-1β concentration in peritoneal lavage of <i>Neo1^−/−</i> and WT animals <b>C</b>) IL-6 concentration in peritoneal lavage of <i>Neo1^−/−</i> and WT animals <b>D</b>) KC concentration in peritoneal lavage of <i>Neo1^−/−</i> and WT animals 8 hours following intraperitoneal NaCl or ZyA injection (Data are Mean ± SEM, n = 6 per group, *P<0.05, **P<0.01, ***P<0.001 as indicated).