Functional inhibition of neogenin dampens release of inflammatory cytokines <i>in-vivo</i>.

<p>WT animals were injected i.p. with NaCl or 1 mg of zymosan A (ZyA) and subsequently i.v. with either IgG control or anti-Neogenin (Anti-Neo1) antibody (1 µg) and peritoneal lavage obtained after 8 hours <b>A</b>) TNF-α concentration in peritoneal lavage <b>B</b>) IL-1β concentration in peritoneal lavage <b>C</b>) IL-6 concentration in peritoneal lavage <b>D</b>) KC concentration in peritoneal lavage of WT animals injected with either vehicle or Anti-Neo1 (Data are Mean ± SEM, n = 6 per group, *P<0.05, **P<0.01, ***P<0.001 as indicated).