Serum levels of miR-513-3p, miR-571 and miR-652 are significantly altered in the serum of patients with chronic liver disease and liver cirrhosis.

<p>(A) Serum levels of the three significantly regulated miRNAs (miR-513-3p; miR-571; miR-652) were analyzed by qPCR in a collective of 17 healthy controls and 67 patients with chronic liver disease and liver cirrhosis. Results are depicted as box plot. The thick line represents the median of relative expression. (B) Receiver operating characteristic (ROC) curve analysis displaying the diagnostic power in predicting cirrhosis of these miRNAs when analyzed as single markers (area under the curve (AUC) 0.87; 0.91; 0.75). (C) ROC curve analysis displaying the diagnostic power in predicting cirrhosis of different combinations of these miRNAs (AUC 0.91; 0.962; 0.9676). **<i>P</i><0.001.