RNAi of TbORC1/CDC6, TbORC4 and Tb7980 in bloodstream form <i>T. brucei</i> cells results in rapid growth arrest.

<p>Growth curves are shown for bloodstream form <i>T. brucei</i> cells in the absence or presence of tetracycline (tet−, shown as solid line, and tet+, dashed line, respectively), which induces RNAi, targeting either <i>TbORC1/CDC6</i>, <i>TbORC4 (Tb13380)</i>, or <i>Tb7980</i> mRNA. For each factor, cell density over time was examined in two clonal RNAi cell lines (identified by C).