<p>In vitro binding potential (BP) as yielded with [<sup>3</sup>H]PiB radioligand saturation binding assay and corresponding soluble and insoluble Aβ<sub>x–40</sub> and Aβ<sub>x–42</sub> protein fractions (picogram protein per milligram wet tissue) for the same human and mouse tissue samples. Binding curves of the severe human AD and all transgenic mouse brain samples are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031310#pone-0031310-g005" target="_blank">Figure 5</a>.</p
Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidi...
<p>(A) Western blot analysis showing levels of mitochondrial proteins TOM40 and TOM20 as well as of ...
Purpose: The objective of this study is the implementation of a kinetic model for C-11-desmethyllope...
<p>Specific [<sup>3</sup>H]PiB binding to mouse and human brain homogenates and nonlinear modeling o...
<p>PET binding potential maps for [<sup>11</sup>C]PiB and corresponding autoradiography and fluoresc...
<p>(A) Western blot of APP and PrP<sup>C</sup> (antibody 6D11) in I5 (n = 3) and J20 (n = 2) transge...
<p>Homogenized insoluble fractions from human brain samples (n = 8) were incubated with increasing c...
Introduction 11C-PIB is a widely-used PET ligand to visualize amyloid beta (Abeta) plaques in vivo. ...
Positron emission tomography (PET) targeting the 18 kDa translocator protein (TSPO) is used to quant...
Introduction 11C-PIB is a widely-used PET ligand to visualize amyloid beta (Abeta) plaques in vivo. ...
The penetration of drugs into the central nervous system is a composite of both the rate of drug upt...
Introduction Previously, development of novel brain radiotracers has largely relied on simple screen...
CHARLES UNIVERSITY IN PRAGUE Faculty of Pharmacy in Hradec Králové Department of Pharmacology and To...
International audienceAssessing the rate of drug delivery to the central nervous system (CNS) in vit...
<p>Levels of α-syn were measured in insoluble fractions from human brain samples (n = 10) by sequent...
Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidi...
<p>(A) Western blot analysis showing levels of mitochondrial proteins TOM40 and TOM20 as well as of ...
Purpose: The objective of this study is the implementation of a kinetic model for C-11-desmethyllope...
<p>Specific [<sup>3</sup>H]PiB binding to mouse and human brain homogenates and nonlinear modeling o...
<p>PET binding potential maps for [<sup>11</sup>C]PiB and corresponding autoradiography and fluoresc...
<p>(A) Western blot of APP and PrP<sup>C</sup> (antibody 6D11) in I5 (n = 3) and J20 (n = 2) transge...
<p>Homogenized insoluble fractions from human brain samples (n = 8) were incubated with increasing c...
Introduction 11C-PIB is a widely-used PET ligand to visualize amyloid beta (Abeta) plaques in vivo. ...
Positron emission tomography (PET) targeting the 18 kDa translocator protein (TSPO) is used to quant...
Introduction 11C-PIB is a widely-used PET ligand to visualize amyloid beta (Abeta) plaques in vivo. ...
The penetration of drugs into the central nervous system is a composite of both the rate of drug upt...
Introduction Previously, development of novel brain radiotracers has largely relied on simple screen...
CHARLES UNIVERSITY IN PRAGUE Faculty of Pharmacy in Hradec Králové Department of Pharmacology and To...
International audienceAssessing the rate of drug delivery to the central nervous system (CNS) in vit...
<p>Levels of α-syn were measured in insoluble fractions from human brain samples (n = 10) by sequent...
Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidi...
<p>(A) Western blot analysis showing levels of mitochondrial proteins TOM40 and TOM20 as well as of ...
Purpose: The objective of this study is the implementation of a kinetic model for C-11-desmethyllope...