Multiple pathways altered after exposure to DSS return to baseline with L-Arg supplementation.

<p>Pathway analysis based on DEGs. (A) 132 genes were found to be upregulated in response to DSS that were subsequently downregulated to control levels after L-Arg supplementation. (B) 27 genes were downregulated in response to DSS and returned to control levels after L-Arg supplementation. (C) Heatmap of the DEGs based on the expression pattern of increased expression after exposure to DSS and decreased expression following L-Arg supplementation. (D) Table showing examples of biologic and signaling pathways, derived from Ingenuity Pathway Analysis, that were found to be affected by these altered gene expression patterns.