Anatomical distribution and evolution of lesions.

<p>EAE mice (n = 9) were immunized with PLP_139–151 peptide (EAE induction) and scored for neurological symptoms on a daily basis. Micro MRI was performed daily starting from d5 post immunization. (A) Shown are seven mice (1–7) exhibiting lesions within the brain – specifically cerebral cortex, cerebellum and subcortical areas (thalamus and striatum) – prior to or during onset of disease. The lower axis indicates the time-points prior to commencement of neurological symptoms (d0). (B) T2W images showing the evolution of cerebellar lesions (arrowhead) from baseline (pre EAE induction) 14 days prior to disease manifestation (d-14) until disease onset (d0). Arrowheads depict enhancement of signal intensity in the white matter over time and dotted islands depict signal extinctions in the vicinity.