GSL-1 treatment inhibits the inflammatory context induced by ADM administration.

<p>BALB/c mice were injected at day 0 with 10 mg/kg of adriamycin (ADM) or treated concomitantly with ADM and 5 µg/mouse GSL-1 (ADM+GSL-1). ADM mice had increased levels of the inflammatory cytokines IL-4, IL-1α, IL-1β, TNF-α, IL-12p40 and IL-17 compared with both the control and GSL-1-treated groups (A to F, respectively). The administration of ADM also induced high levels of inflammatory chemokines, such as RANTES and eotaxin, which were inhibited by GSL-1 treatment (G and H, respectively). These data indicate an inhibitory effect for GSL-1 treatment, supporting its renoprotective effect. * p<0.05 vs. control; # p<0.05 vs. ADM.