Removal of striatal PNNs improves Morris water maze acquisition.

<p>A significant interaction between treatment Group and training Days was observed in terms of latency to goal (Repeated measures ANOVA, group versus days interaction, <i>P</i> = 0.013) (A). Closer analysis revealed that ChABC treated animals (red) took significantly shorter amounts of time to find the submerged platform on Days 2 and 4 (ANOVA, P<0.05). (B) Although both ChABC (red dotted) and vehicle (grey dotted) treated groups exhibited a preference for the quadrant that previously contained the submerged platform (Quadrant D; inset), no significant difference was observed between the two groups. (C) Sample hemispheres of ChABC (left) and saline (right) treated striatum from animals that had completed behavioral testing. PNNs remained digested even after two weeks of training. Scale bar: 1 mm.