a<p>Decay of LD with physical distance were fitted according to Ohta and Kimura (1969) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033470#pone.0033470-Ohta1" target="_blank">[37]</a> model: E (r<sup>2</sup><sub>ij</sub>) = 1/(1+4Neρd<sub>ij</sub>ρ). Where, r<sup>2</sup><sub>ij</sub> stands for the LD value between markers i and j, Ne for the effective population size, ρ for the per base recombination rate and d<sub>ij</sub> for the distance in base pairs between markers i and j. The analysis was performed with the nls function in R. The composite parameter a = Neρ was estimated for the whole CS and the different genetic groups.</p>b<p>Achieved convergence tolerance obtained with the nls function in R.</p
<p>Box plot of the distance between any associated SNP and causal variant it is in highest LD with, ...
We have developed a simple yet powerful approach for disease gene association mapping by linkage dis...
<p>LD measures <i>r<sup>2</sup></i> against genetic map distance between pairs of SNP markers within...
<p>The relationship between LD and map distance was modeled by fitting two alternate non-linear regr...
<p>LD extent was computed with 43224 SNPs having MAF>0.05.</p>a<p>Physical distance to reach <i>r<su...
<p><sup>a</sup> Average physical distance (in Mb) between adjacent markers.</p><p><sup>b</sup> Avera...
Allelic association between pairs of loci is derived in terms of the association probability ρ as a ...
The horizontal dashed line indicates the average linkage between markers on different chromosomes. L...
<p>* Number of marker pairs included in each class. The analysis of linkage disequilibrium (LD) reve...
<p>(A) <i>Across sample comparison of Median of LD (D′) as a function of pairwise distance between S...
High-throughput genotyping technologies for SNPs have enabled the recent completion of the Internati...
High-throughput genotyping technologies for single nucleotide polymorphisms (SNP) have enabled the r...
<p>The values in the map are the normalized measures of allelic association |D’| (<b>A</b>) and corr...
<p><i>r<sup>2</sup></i> estimates were plotted against the average map distance (recombination frequ...
The horizontal line indicates the 90th percentile distribution of unlinked r2.</p
<p>Box plot of the distance between any associated SNP and causal variant it is in highest LD with, ...
We have developed a simple yet powerful approach for disease gene association mapping by linkage dis...
<p>LD measures <i>r<sup>2</sup></i> against genetic map distance between pairs of SNP markers within...
<p>The relationship between LD and map distance was modeled by fitting two alternate non-linear regr...
<p>LD extent was computed with 43224 SNPs having MAF>0.05.</p>a<p>Physical distance to reach <i>r<su...
<p><sup>a</sup> Average physical distance (in Mb) between adjacent markers.</p><p><sup>b</sup> Avera...
Allelic association between pairs of loci is derived in terms of the association probability ρ as a ...
The horizontal dashed line indicates the average linkage between markers on different chromosomes. L...
<p>* Number of marker pairs included in each class. The analysis of linkage disequilibrium (LD) reve...
<p>(A) <i>Across sample comparison of Median of LD (D′) as a function of pairwise distance between S...
High-throughput genotyping technologies for SNPs have enabled the recent completion of the Internati...
High-throughput genotyping technologies for single nucleotide polymorphisms (SNP) have enabled the r...
<p>The values in the map are the normalized measures of allelic association |D’| (<b>A</b>) and corr...
<p><i>r<sup>2</sup></i> estimates were plotted against the average map distance (recombination frequ...
The horizontal line indicates the 90th percentile distribution of unlinked r2.</p
<p>Box plot of the distance between any associated SNP and causal variant it is in highest LD with, ...
We have developed a simple yet powerful approach for disease gene association mapping by linkage dis...
<p>LD measures <i>r<sup>2</sup></i> against genetic map distance between pairs of SNP markers within...