Hepatitis C virus cleaves antiviral factor MAVS to evade host detection (left diagram, top). Adaptive changes (red shields) close to the cleavage site provide protection from this antagonism and have occurred in multiple primate species via convergent evolution (right diagram).

<p>Hepatitis C virus cleaves antiviral factor MAVS to evade host detection (left diagram, top). Adaptive changes (red shields) close to the cleavage site provide protection from this antagonism and have occurred in multiple primate species via convergent evolution (right diagram).