Non-random distribution of <i>Toxoplasma</i> cysts in mouse brains.

<p>(A) Cyst frequency and distribution in different mouse brain areas (n = 23). (B) Lorenz curve of cumulative cyst presence in relation to relative brain volume of specific areas. Cyst distribution deviated from perfect equality and was therefore not random. (C) Representation of the quadrant intersection [C1(+) C2(+)] of the cyst localization PCA space (shaded area). Animals with loadings in this quadrant (red dots) were not different from the rest of the animals with brain cysts, for behavioral component F4. (D) Infected animals which co-clustered in the [C1(+) C2(+)] quadrant of the cyst localization PCA space (n = 3) did not show significantly higher factor loadings for behavioral component 4 (F4) than animals that did not cluster in this quadrant (n = 16). (E) Representation of the quadrant intersection [C1(−) C3(−)] of the cyst localization PCA space (shaded area). Animals with high loading values for behavioral component F5 cluster in this quadrant (red dots). (F) Infected animals which co-clustered in the C1(−) C3(−) quadrant of the cyst localization PCA space (n = 7) showed significantly higher factor loadings for behavioral component 5 (F5) than animals that did not cluster in this quadrant (n = 12). Hippoc, hippocampus; Amyg, amygdala; Motor cx, motor cortex; Cpu, caudate putamen; Acc Ncl, accumbens nucleus; VTA, ventral tegmental area; Pirif cx, piriform cortex; Olfac tract, olfactory tract; Somats cx, somatosensory cortex; Aud cx, auditory cortex; Vis cx, visual cortex; Orbital cx, orbital cortex; Thalam, thalamus; Lat sep nucl, lateral septal nucleus; Agrn insl cx, agranular insular cortex; Retrospl dysg cx, retrosplenial dysgranular cortex; Prelimb cx, prelimbic cortex; Periaqued gray, periaqueductal gray; Cg cx, cingulate cortex; Hypothal, hypothalamus; Assoc cx, association cortex.