Association of the selected serum miRNA levels with GC differentiation grades and DYS.

<p>(A–C) Box plots of serum miR-221, miR-376c and miR-744 levels in 24 well or moderately differentiated and 43 poorly differentiated GC patients. (D–F) Box plots of serum miR-221, miR-376c and miR-744 levels in 46 DYS subjects and matched controls. The Mann-Whitney U tests (A–C) and the Wilcoxon tests (D–F) were performed to examine the difference between two groups, respectively. The relative levels of miRNAs (log10 scale at Y-axis) were normalized to the spiked-in cel-miR-39 (A–F).