The role of <i>C. albicans</i> spatial orientation in engulfment by J774.1 macrophages.

<p><a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002578#ppat-1002578-g007" target="_blank">Figure 7A</a> plots the time taken for engulfment of individual hyphal wildtype <i>C. albicans</i> in relation to the exact angles at which cell-cell contact was established (0°, side-on; 90°, end-on). <i>C. albicans</i> can be engulfed in any spatial orientation, including end-on, side-on and at an angle (<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002578#ppat-1002578-g007" target="_blank">Figure 7A</a>). <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002578#ppat-1002578-g007" target="_blank">Figures 7B–E</a> show snapshots from live cell video microscopy movies showing <i>C. albicans</i> being taken up in a variety of orientations, including yeast end on, (<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002578#ppat-1002578-g007" target="_blank">Figure 7B</a>), germ tube apex end-on (<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002578#ppat-1002578-g007" target="_blank">Figure 7C</a>), side-on (7D) and at an angle (7E). Scale bar, 10 µm; macrophage of interest, *.