Protective efficacy of influenza-LACK_158–173 vaccination.

<p>A) Lesion scores in mice vaccinated with LACK_ins and PR 8 vector controls (pooled data from 2 independent experiments). B) Parasite burdens in mice vaccinated with LACK_ins (n = 5), PR 8 vector control (n = 5), *<i>p</i> = 0.02. C) Cytokine production following challenge infection. Spleens and dNL from vaccinated and control mice were assessed by <i>ex vivo</i> ICS IFN-γ (*<i>p</i> = 0.006). Mean, pooled data from 2 independent experiments ± SEM are plotted (n = 6 for wk 2, n = 5 for wk 6, n refers to number of mice). Cells have been gated on CD4⁺ CD44⁺.