NCR1-dependent bone loss.

<p>(A) Mesio-distal view on a random section. Red, yellow, gray and green represent the enamel, dentin, bone and the residual bone area above the reference line, respectively. (B) Ncr1<i>^+/+</i> (WT) and Ncr1<i>^gfp/gfp</i> (KO) mice (n = 8 in each group) were challenged orally three times at 2-day intervals with inoculums of <i>F. nucleatum</i> and of <i>P. gingivalis</i> (2×10⁸ CFU in 0.2 ml of PBS and 2% carboxymethylcellulose). Six weeks later, the jaws were harvested and the residual alveolar bone volume (mm³×10⁻³) was measured. Error bars represent SD. Data represent percentage of bone loss ± SD and are average of two independent experiments. ** <i>p</i><0.01. The difference in bone loss between the KO and the WT mice following <i>P. gingivalis</i> inoculation was not statistically significant, <i>p</i><0.09.