Mouse skin papillomas induced by DMBA/TPA.

<p>(A) Papillomas induced by DMBA/TPA treatment in <i>JWA^+/+</i> mouse skin (left). Arrow indicates the papilloma. (B) Comparison of the percentage of papilloma-free mice between <i>JWA^+/+</i> and <i>JWA</i>^{Δ<i>2/</i>Δ<i>2</i>} groups after DMBA/TPA treatment. ***<i>P</i><0.001. (C) Comparison of average numbers of papillomas per mouse between <i>JWA^+/+</i> and <i>JWA</i>^{Δ<i>2/</i>Δ<i>2</i>} groups. ***<i>P</i><0.001. (D) Comparison of papilloma size distribution between <i>JWA^+/+</i> and <i>JWA</i>^{Δ<i>2/</i>Δ<i>2</i>} groups. The diameter of papillomas was used to represent the tumor size. *<i>P</i><0.05, **<i>P</i><0.01. (E) H&E staining for typical papillomas from both <i>JWA^+/+</i> and <i>JWA</i>^{Δ<i>2/</i>Δ<i>2</i>} mice.