Effect of GM3 and GD3 on APP processing.

<p>(<i>A</i>) Dose-dependent effect of GM3 on Aβ production: COS7 cells stably transfected with SPC99, representing the β-secretase cleaved C-terminal fragment of APP, show a dose-dependent decrease in Aβ production in presence of GM3. Aβ levels were determined by IP and Western blot (WB) analysis. (<i>B</i>) Dose-dependent effect of GD3 on Aβ generation in SPC99 expressing COS7 cells. GD3 enhances Aβ generation dose-dependently. Aβ levels were determined by IP and WB analysis.