<p>Readthrough efficiencies of 66 sequences (65 nonsense mutations and 1 natural stop codon) were measured in NIH3T3 cells with and without gentamicin (800 µg/ml) treatment for 24 H. Each value shown is the mean of at least three independent experiments. For each sequence, the factor of increase (I) is the ratio of the gentamicin-induced readthrough level (G) to the basal readthrough level (B). Sequences are ranked in descending order of gentamicin-induced readthrough level.</p
<p>Gentamicin-induced readthrough level is plotted against basal readthrough level (A); the factor o...
The read-through rate is estimated by the ribosome profiling RPKM of region 1 relative to that of th...
The APC tumor suppressor gene is frequently mutated in human colorectal cancer, with nonsense mutati...
The efficiency of translation termination depends on the nature of the stop codon and the surroundin...
<p>For DMD 319 and DMD 673, a U residue immediately upstream from the stop codon (−1) was replaced b...
<p>Graphical representation of medians (before Box-Cox transformation) for the parameters B, G and I...
<p>Readthrough efficiencies for 11 nonsense mutations in the APC gene were assessed in NIH3T3 cells ...
<p>Hierarchies were established based on ANOVA/LSD tests after normalization of B, G and I. The sign...
Nonsense mutations, resulting in a premature stop codon in the open reading frame of mRNAs are respo...
Nonsense mutations, resulting in a premature stop codon in the open reading frame of mRNAs are respo...
Nonsense mutations are quite prevalent in inherited diseases. Readthrough drugs could provide a ther...
Nonsense mutations are quite prevalent in inherited diseases. Readthrough drugs could provide a ther...
International audienceNonsense mutations introduce premature termination codons and underlie 11% of ...
Series: JIMD Reports, 2192-8304 ; 13The premature stop codon mutations, Q70X and W402X, are the most...
<p>The APC 1114 and APC 1131 nonsense mutations originally had a U residue in the −1 position, which...
<p>Gentamicin-induced readthrough level is plotted against basal readthrough level (A); the factor o...
The read-through rate is estimated by the ribosome profiling RPKM of region 1 relative to that of th...
The APC tumor suppressor gene is frequently mutated in human colorectal cancer, with nonsense mutati...
The efficiency of translation termination depends on the nature of the stop codon and the surroundin...
<p>For DMD 319 and DMD 673, a U residue immediately upstream from the stop codon (−1) was replaced b...
<p>Graphical representation of medians (before Box-Cox transformation) for the parameters B, G and I...
<p>Readthrough efficiencies for 11 nonsense mutations in the APC gene were assessed in NIH3T3 cells ...
<p>Hierarchies were established based on ANOVA/LSD tests after normalization of B, G and I. The sign...
Nonsense mutations, resulting in a premature stop codon in the open reading frame of mRNAs are respo...
Nonsense mutations, resulting in a premature stop codon in the open reading frame of mRNAs are respo...
Nonsense mutations are quite prevalent in inherited diseases. Readthrough drugs could provide a ther...
Nonsense mutations are quite prevalent in inherited diseases. Readthrough drugs could provide a ther...
International audienceNonsense mutations introduce premature termination codons and underlie 11% of ...
Series: JIMD Reports, 2192-8304 ; 13The premature stop codon mutations, Q70X and W402X, are the most...
<p>The APC 1114 and APC 1131 nonsense mutations originally had a U residue in the −1 position, which...
<p>Gentamicin-induced readthrough level is plotted against basal readthrough level (A); the factor o...
The read-through rate is estimated by the ribosome profiling RPKM of region 1 relative to that of th...
The APC tumor suppressor gene is frequently mutated in human colorectal cancer, with nonsense mutati...