3D structures of AncCR, AncGR1 and AncGR2.

<p>AncCR was within 2.5 Å all-atom RMSD from the experimentally determined AncCR. AncGR1 was within 2.9 Å all-atom RMSD from the experimentally determined crystal structure. AncGR2 was within 2.8 Å all-atom RMSD from the experimentally determined AncGR2. Included for reference is a cartoon figure with helices labeled for reference and the ligand is bound, represented in blue spheres.