Class I phenotypically plastic transcription factors.

<p>(A) Diagram of the relationship between transcription factor regulation and rearing conditions. The 25 environmentally sensitive transcription factor transcripts are shown in circles and 16 treatment conditions are shown in magenta font in rectangular boxes. Red and blue lines designate up- and down- regulation of the transcription factor, respectively, under different treatments. Designations are: HSK, heatshock; STARV, starvation; DOP, dopamine (DOP); HY, high yeast; HT, high temperature; LT, low temperature; HS, high sugar; LC, larval crowding; AG, aging; CC, chill coma; NIC, nicotine: AC, adult crowding; VG, virgin; CL, constant light; MEN, menadione; HSHY, high sugar-high yeast. (B) Interaction networks of phenotypically plastic transcription factors. Interaction networks of the 25 transcription factors (red nodes) were analyzed through the <i>Drosophila</i> Interaction Database (DroID) <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002593#pgen.1002593-Yu1" target="_blank">[36]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002593#pgen.1002593-Murali1" target="_blank">[37]</a>. The diagram shows protein-protein interactions (green edges), genetic interactions (blue edges), protein-DNA interactions (red edges), interactions that involve both protein-protein, genetic and/or protein-DNA interactions (magenta edges), and interactions with miRNAs (pink edges). Interactions with single transcription factors are shown around the periphery, whereas multiple interactions between transcription factors and interactions between genes (or micro RNAs) and multiple transcription factors are shown inside the circle. Transcription factors are clockwise starting from the arrow: <i>bowl, ara, caup, cbt, exex, CG1617, trh, ci, net, ERR, lmd, repo, ptx1, scro, Sox102F, sug, vg, D, vnd, dei, odd, nub, esg,</i> and <i>peb</i>. Only three interactions are documented for <i>bigmax</i>, shown as a separate diagram.