Effect of the MOI on the interactions between J774 macrophages and yeasts over 24-hour time course experiments.

<p>(A) Interactions of J774 macrophages and stationary-phase living yeasts at 1M:5Y MOI. Note that more macrophages died with <i>C. glabrata</i> and <i>C. lusitaniae</i> than at 1M:1Y MOI at T 24 h. Again the highest part of phagocytosing macrophages and macrophage cell death rates were obtained with <i>C. albicans</i>. Note the higher uptake of <i>C. glabrata</i> cells, and the escape from macrophages of the three <i>Candida</i> species at T 24 h. (B) Interactions of J774 macrophages and stationary-phase living yeasts at 5M:1Y MOI. Note that the macrophage killing with <i>C. albicans</i> was delayed compared to 1M:1Y MOI. Note the equally high uptake of <i>C. glabrata</i> and <i>C. lusitaniae</i> and the lower uptake of <i>C. albicans</i> biomass, that was the only one species that finally escaped the macrophages at that 5M:1Y MOI. For the legend description, please refer to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032621#pone-0032621-g003" target="_blank">Figure 3</a>.